• Atg cleaves Atg at the peptide bond on the

  2020-08-10

  

  Atg4 cleaves Atg8 at the peptide bond on the glycine residue at the C-terminus, thus allowing the conjugation of Atg8 to phosphatidylethanolamine (PE) with the participation of other autophagy molecules. Atg4 can also serve as a deconjugating enzyme, which cleaves the amide bond of the conjugated At

• LTD and LTC cause contraction in the

  2020-08-10

  

  LTD4 and LTC4 cause contraction in the rat stomach and these contractions are sensitive to CysLT1 receptor antagonists (Goldenberg and Subers, 1983, Miura et al., 1992, Miyata et al., 1995). However, effects of other leukotrienes in the gastric contraction and inhibitory effects of potent, selective

• In we studied normal rational

  2020-08-10

  

  In [1] we studied normal, rational -varieties X of complexity one, where the latter means that X comes with an effective torus action such that holds. We showed that for affine X with and at most log terminal singularities, the iteration of Cox rings is possible. In the present article, we charac

• SS is a high grade

  2020-08-10

  

  SS is a high-grade malignant soft tissue sarcoma accounting for 5%–10% of soft tissue sarcomas. After RMS, SS is the most common sarcoma in children, adolescents and young adults [9]. SS originates primarily in the lower (62%) and upper (21%) extremities but may occur at any anatomic site [9], [10].

• br Transparency document br Acknowledgments This study was f

  2020-08-10

  

  Transparency document Acknowledgments This study was funded by ICMR, Govt. of India. Alisha Dhiman acknowledges UGC-DSKPDF, India for post-doctoral fellowship and Monisha Gopalani acknowledges CSIR, India for Senior Research Fellowship. AIRF, JNU is acknowledged for TEM, confocal microscopy an

• In addition to playing important roles in the immune system

  2020-08-10

  

  In addition to playing important roles in the immune system, EBI2 is also expressed in the bx795 receptor of the central nervous system (CNS), namely astrocytes, and this receptor regulates astrocyte signalling, as well as astrocyte cell migration (Rutkowska et al., 2015, Rutkowska et al., 2016a). M

• br Experimental methods br Results and discussion br Conclus

  2020-08-08

  

  Experimental methods Results and discussion Conclusion Rational design of highly selective fluorescent probes to detect G-quadruplexes is of profound importance for basic research. On this basis, we designed and synthesized a series of N-alkylated styrylquinolinium dyes Ls-1, Ls-2 and Ls-3.

• The question remained as to

  2020-08-08

  

  The question remained as to why hCrm1 was functional and mCrm1 was not in terms of Rev and HIV mRNA nuclear export, and previously we proposed three possibilities (Elinav et al., 2012). One was that human Eltrombopag had a positively acting factor that somehow stabilized the hCrm1 and Rev-RRE compl

• br Materials and Methods br Results br Discussion Mitochondr

  2020-08-08

  

  Materials and Methods Results Discussion Mitochondrion not only generates energy but also produces ROS under physiological conditions. However, overnutrition causes mitochondrial congestion and elicits excessive ROS generation, leading to insulin resistance (Muoio, 2014, Houstis et al., 200

• The T cell receptor TCR pathway is associated with T

  2020-08-08

  

  The T cell receptor (TCR) pathway is associated with T cell activation and differentiation. When specific antigen peptides are recognized by the TCR, lymphocyte-specific protein tyrosine kinase (lck) phosphorylates the immune-receptor tyrosine-based activation motifs (ITAMs) of the TCR-CD3 complex a

• Asb genes are characterized by the presence of

  2020-08-08

  

  Asb genes are characterized by the presence of a conserved SOCS box motif and a variable number of ankyrin repeats. The SOCS box is a structural C-terminal domain that interacts with Elongin C via its B/C box conserved motif. In turn, Elongin C binds Elongin B to form a dimer that bridges the substr

• What would be the possible off target effects of

  2020-08-08

  

  What would be the possible off-target effects of enhancing Ndfip1 to control T cell responses? Increasing Ndfip1 activity could limit cytokine production in macrophages, where it has been shown to function in mouse BMDMs to degrade Tak1 and downregulate NFκB signaling [108]. Whether Ndfip1 regulates

• Tamoxifen was approved by the US

  2020-08-07

  

  Tamoxifen was approved by the US Food and Drug Administration in 1977 (Del Re et al., 2012) and it has been used as an agent of choice in the treatment of hormone responsive breast tumors for over four decades. Furthermore, this drug is prescribed as a chemo-preventive agent for high-risk women who

• CMV replication is highly dependent on beneficial host

  2020-08-06

  

  CMV replication is highly dependent on beneficial host cell translation functions. As a major regulator of cap-dependent translation initiation, the activation of mTOR is essential for CMV. Activated mTOR can phosphorylate 4E-BP, eIF4G, and S6K. Further, phosphorylation of 4E-BP and eIF4G can mainta

• Herein we explored by docking studies the effectiveness of r

  2020-08-06

  

  Herein, we explored by docking studies the effectiveness of replacing the dimethyl substitution at C (6) of dihydrotriazine with a folded azaspiro-containing substituent, along with the introduction of differently substituted phenyl- and benzyl-rings or alkyl chains, linked at the position 1 of the

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